K+/H+-antiporter nigericin arrests DNA synthesis in Ehrlich ascites carcinoma cells
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چکیده
منابع مشابه
K+/H+-antiporter nigericin arrests DNA synthesis in Ehrlich ascites carcinoma cells.
Acidification of the cytoplasm of Ehrlich ascites carcinoma cells to pH 6.3 arrests DNA synthesis in these cells. Such an effect can be achieved by incubating the cells at pH 6.2 or by adding low concentrations of the K+/H+ antiporter, the antibiotic nigericin, at neutral pH. Glucose and anaerobiosis potentiate the nigericin effect. The inhibition of DNA synthesis by nigericin occurs without an...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1989
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.86.17.6626